Автор | Brown, Evelyn |
Автор | Sheppard, Robert C. |
Автор | Williams, Brian J. |
Дата выпуска | 1983 |
dc.description | A procedure is described for the solid-phase synthesis of gastrin peptides exemplified by [15-leucine]little gastrin. The method makes use of a polar polyamide resin support and stepwise addition of fluorenylmethoxycarbonylamino-acid derivatives. Treatment with acidic reagents is minimised, obviating the need for side-chain protection of tryptophan and eliminating acid-catalysed side reactions at the multiple glutamyl residues. Formation of the terminal pyroglutamyl residue was achieved through a glutaminyl intermediate. |
Формат | application.pdf |
Издатель | Royal Society of Chemistry |
Название | Peptide synthesis. Part 5. Solid-phase synthesis of [15-leucine]little gastrin |
Тип | research-article |
DOI | 10.1039/P19830001161 |
Electronic ISSN | 1364-5463 |
Print ISSN | 0300-922X |
Журнал | Journal of the Chemical Society, Perkin Transactions 1 |
Первая страница | 1161 |
Последняя страница | 1167 |