Asymmetric conjugate addition of Grignard reagents in the presence of tertiary amines to α,β-unsaturated amides derived from (S)-2-(1-hydroxy-1-methylethyl)pyrrolidine or (S)-prolinol
Soai, Kenso; Machida, Hideaki; Ookawa, Atsuhiro
Журнал:
Journal of the Chemical Society, Chemical Communications
Дата:
1985
Аннотация:
In the presence of tertiary amines, diastereoselective conjugate addition of Grignard reagents to α,β-unsaturated amides affords 3-substituted carboxylic acids of high enantiomeric excess (up to 89% e.e.).
182.0Кб